Dimitrios Kalpaxis





Academic Position

Professor of Biochemistry

Vice-Rectror for the strategic planning and research development of the University of Patras

Εducation and Positions

ΒSc in Biology, Univ. of Patras 1974

BSc in Chemistry, Univ. of Patras 1979

PhD in Biochemistry, School of Sciences, Univ. of Patras 1981

Research Interests

Mechanism of antibiotic action against protein synthesis

Role of monovalent and divalent ions and polyamines during protein synthesis

Studies on specific mutations in ribosomal components and their effect on the function of ribosome

Use of protein synthesis as a bio-marker in environmental surveillance studies

Representative publications

1. I. Amarantos, and D. L. Kalpaxis (2000). Photoaffinity polyamines: interactions with AcPhe-tRNA free in solution or bound at the P-site of Escherichia coli ribosomes. Nucleic Acids Res., 28, 3733-3742.

2. G. Dinos, D. Wilson, Y. Teraoka, W. Szaflarski, P. Fucini, D. L. Kalpaxis and K. H. Nierhaus (2003). Dissecting the inhibition mechanisms of edeine and pactamycin: Antagonistic interplay on the ribosome between these translational inhibitors. Mol. Cell, 13, 113-124

3. A. Petropoulos, M. A. Xaplanteri, G. P. Dinos, D. N. Wilson and D. L. Kalpaxis (2004). Polyamines affect diversely the antibiotic potency: insight gained from kinetic studies of the blasticidin S and spiramycin with functional ribosomes. J. Biol.Chem., 279, 26518-26525.

4. E. C. Kouvela, A. D. Petropoulos and D. L. Kalpaxis (2006) Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J. Biol. Chem., 281, 23103-23110.

5. M. A. Xaplanteri, G. Papadopoulos, F. Leontiadou, T. Choli-Papadopoulou and D. L. Kalpaxis (2007) The contribution of the zinc-finger motif to the function of Thermus thermophilus ribosomal protein S14. J. Mol. Biol., 369(2):489-97.

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