CV


Name

Constantinos Stathopoulos


Position

Associate Professor


email
cstath@med.upatras.gr

telephone
+302610997932


Academic Position

Associate Professor of Biochemistry



Εducation and Positions

BSc. in Biology, Univ. of Patras 1991

PhD in Biochemistry, School of Medicine, Univ. of Patras 1996

Postdocoral research associate. Yale University, USA 1998-2002

Assistant Prof. of Biochemistry, Dept. of Biochemistry & Biotechnology, Univ. of Thessaly 2002-2009



Research Interests

Functional genomic analysis of enzymes that are involved in the biogenesis and aminoacylation of tRNAs in pathogens

tRNA-dependent exo-ribosomal peptide biosynthesis in pathogens. Detection of new molecular targets for antibiotics

Studies on La protein as regulator of tRNA and rRNA biogenesis

Detection and biochemical characterization of mitochondrial tRNA mutations that are associated with severe clinical phenotypes in human populations

tRNA-dependent regulation through riboswitches

Studies on the activities and regulation of mRNA turnover through deadenylation



Representative publications

 

1. Stathopoulos C., Li T., Longman R., Vothknecht U.C., Becker H.D., Ibba M. and Söll D. (2000). One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287: 479-482.

2. Stathopoulos C., Kim W., Li T., Anderson I., Palioura S., Whitman W. and Söll D. (2001) Cysteinyl-tRNA synthetase is not essential for the viability of the archeaon Methanococcus maripaludis. Proc. Natl. Acad. Sci. USA 98: 14292-14297.

3. Kamtekar S., Kennedy D.W., Wang J., Stathopoulos C., Söll D. and Steitz, T.A. (2003) The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases Proc. Natl. Acad. Sci. USA 100: 1673-1678.

4. Ruan B., Bovee M.L., Sacher M., Stathopoulos C., Poralla K., Francklyn C.S. and Söll D. (2005) A unique hydrophobic cluster near the active site contributes to differences of borrelidin inhibition among threonyl-tRNA synthetases. J. Biol. Chem. 280: 571-577. (ΙF: 4.773)

5. Bailly M., Giannouli S., Blaise M., Stathopoulos C., Kern D and Becker H. D. (2006) A single tRNA base-pair mediates bacterial tRNA-dependent biosynthesis of asparargine. Nucleic Acids Res. 34: 6083-6094

6. Zifa E., Giannouli S., Theotokis P., Stamatis K., Mamuris Z. and Stathopoulos C. (2007) Mitochondrial tRNA mutations: functional and clinical perturbations. RNAbiology 4: 38-66

7. Giannouli S., Kyritsis A., Malissovas N., Becker H. D. and Stathopoulos C. (2009) On the role of an unusual tRNAGly isoacceptor in Staphylococcus aureus. Biochimie

8. Giannouli S., Labrou M., Kyritsis A., Ikonomidis A., Pournaras S., Stathopoulos C. and Tsakris A. (2010) Detection of mutations in FemABX protein family in oxacillin-susceptible, mecA positive Staphylococcus aureus clinical isolates J. Antimicrob. Chemoth. 65: 626-633

9. Pournaras S., Ntokou E., Zarkotou O., Ranellou K., Themeli-Digalaki K., Stathopoulos C. and Tsakris A. (2013) Emergence of linezolid-dependent Staphylococcus epidermidis bloodstream isolates. Emerging Infect. Dis. 19: 129-132

10. Saad N. Y., Stamatopoulou V., Drainas D., Stathopoulos C. and Becker H. D. (2013) Τwo-codon T-box riboswitch binding two tRNAs. Proc. Natl. Acad. Sci. published ahead of print July 15, 2013, doi:10.1073/pnas.1304307110

 

 



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