CV


Name

Constantinos Stathopoulos


Position

Associate Professor


email
cstath@med.upatras.gr

telephone
+302610997932


Academic Position

Associate Professor of Biochemistry



Εducation and Positions

BSc. in Biology, Univ. of Patras 1991

PhD in Biochemistry, School of Medicine, Univ. of Patras 1996

Postdocoral research associate. Yale University, USA 1998-2002

Assistant Prof. of Biochemistry, Dept. of Biochemistry & Biotechnology, Univ. of Thessaly 2002-2009 



Research Interests

Functional genomic analysis of enzymes that are involved in the biogenesis and aminoacylation of tRNAs in pathogens

tRNA-dependent exo-ribosomal peptide biosynthesis in pathogens. Detection of new molecular targets for antibiotics

Studies on La protein as regulator of tRNA and rRNA biogenesis

Detection and biochemical characterization of mitochondrial tRNA mutations that are associated with severe clinical phenotypes in human populations

tRNA-dependent regulation through riboswitches

Studies on the activities and regulation of mRNA turnover through deadenylation



Representative publications

1. Stathopoulos C., Li T., Longman R., Vothknecht U.C., Becker H.D., Ibba M. and Söll D. (2000). One polypeptide with two aminoacyl-tRNA synthetase activities. Science 287: 479-482.

2. Kamtekar S., Kennedy D.W., Wang J., Stathopoulos C., Söll D. and Steitz, T.A. (2003) The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases  Proc. Natl. Acad. Sci. USA 100: 1673-1678.

3. Korencic D., Ahel I., Schelert J., Sacher M., Ruan B., Stathopoulos C., Blum P., Ibba, M. and Söll D. (2004) A freestanding proofreading domain is required for protein synthesis quality control in archaea. Proc. Natl. Acad.  Sci. USA 101: 10260-10265.

4. Bailly M., Giannouli S., Blaise M., Stathopoulos C., Kern D and Becker H. D. (2006) A single tRNA base-pair mediates bacterial tRNA-dependent biosynthesis of asparargine. Nucleic Acids Res. 34: 6083-6094.

5. Balatsos N. A. A., Vlachakis D., Maragozidis P., Manta S., Anastasakis D., Kyritsis A., Vlassi M., Komiotis D. and Stathopoulos C. (2009) Synthetic purine and pyrimidine nucleotide analogues with anti-cancer activity inhibit human poly(A) specific ribonuclease (PARN). Biochemistry 48: 6044-6051.



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