CV


Name

George Dinos


Position

Associate Professor


email
dinosg@upatras.gr

telephone
+302610996125


Academic Position

Asspciate Professor of Biochemistry

Εducation and Positions

BSc., in Chemistry, Univ. of Athens 1979

PhD in Biochemistry, School of Medicine, Univ. of Patras 1995



Research Interests

Ribosome biogenesis

Development of inhibitors for ribosome biogenesis

Combined functional and crystal structure studies of new ketolides effective against macrolides resistant strains



Representative publications

1. Dinos G, Wilson D, Teraoka Y, Fucini P, Kalpaxis D and Nierhaus K. (2004) Dissecting the inhibition mechanisms of edeine and pactamycin: Antagonistic interplay on the ribosome between these translational inhibitorsMoll Cell 13: 113-124.

2. Petropoulos A, Kouvela E, Dinos G, and Kalpaxis D (2008) Stepwise Binding of Tylosin and Erythromycin to Escherichia coli Ribosomes, Characterized by Kinetic and Footprinting Analysis. J Biol Chem 283(8):4756-65.

3. Petropoulos AD, Kouvela EC, Starosta AL, Wilson DN, Dinos GP and Kalpaxis DL (2008) Time-resolved binding of azithromycin to Escherichia coli ribosomes. J Mol Biol. 385:1179-1192.

4. Kouvela EC, Kalpaxis DL, Wilson DN, and Dinos GP (2009) A distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. Antimicrob Agents Chemother. 53:1411-1419.

5. Krokidis MG, Kostopoulou ON, Kalpaxis DL, and Dinos GP. (2010) Dissecting the ribosomal inhibition mechanism of a new ketolide carrying an aryl-alkyl group at C-13 of its lactone-ring. International Journal of Antimicrobial Agents, 35:235-239.



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